I want to preface this post by encouraging you to be open-minded, even if you think you absolutely cannot run. At 253 pounds, I never, in my wildest dreams, could have imagined I would one day run one mile, let alone a whole marathon. Yes, there are people who have health conditions or ailments that prevent them from running, and of course you should listen to your doctor; but, if you have the doctor's go-ahead, then I believe that just about anyone can run a mile.
I only write that because it makes me sad when I hear someone say, "Oh, I could never be a runner." I felt the same way... until I became one ;)
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